The new growth of areolar tissue is a very widely extended one. Newly generated areolar tissue occurs both pure, and also as a constituent of other new formations, for which it often furnishes a sort of stroma or framework. Generally speaking, it is not alone as to the constitution of, but also as to the arrangement of its fibres in new growths, a repetition of the normal. In the said stroma or framework, however, of many cancerous growths, there occur fibrils of extraordinary delicacy.

Its development often follows the laws of the cell-theory, that is nucleus, cell-formation, spindle-shaped, caudate cell, fibre with attached nucleus, fusion of several cells to a varicose fibre, breaking up of the fibres into fibrils. Areolar tissue is, however, much more frequently and more extensively shaped out of the immediate dissilience of a solid blastema into areolar tissue fibre, or else mediately, through a preliminary splitting into other coarser fibres.

Newly formed areolar tissue is often found blended in different proportions with elastic fibres, nucleus fibres in various degrees of development, from the oblong, caudate nucleus, the rodlike fibre stem, to the complete fibre.

Apart from its occurrence as mere increment of that previously existing (hypertrophy) - areolar tissue of new formation is met with:

(a.) In the shape of threaden, cord-like growths, of flocculent and velvety accumulations, of either free, bridle-like, or agglutinated and firmly seated layers and membranes upon serous tunics, even of entirely new-formed, movable, serous sacs. In many such cases it is, as membrane, invested with an epithelium on its inner free surface.

It determines those frequent adhesions of organs contained within serous sacs, both with each other, and with the parietes of the latter.

(b.) It constitutes the entire parietes of perfectly new anomalous serous and synovial sacs, or else it partially enters into their composition for the most part as the external layer, in connection with fibroid textures. To this class belong the anomalous bursae mucosae, the articular capsules of preternatural joints, the capsules investing foreign bodies or extrava-sate (the envelopes of apoplectic cysts), every variety of cyst-formation.

(c.) It forms the external vascular sheath of many new growths, both benign and malignant, fibroid and cancerous, or their stroma, for example in lipoma.

(d.) Of tumors it forms the condyloma, the hypertrophous lupus, the pedunculated wart. Commonly conjoined with fatty texture, it composes those appendices of the skin denominated mollusca, a species of so-called fibrous tumors and of fibrous polypi.

(e.) Finally it presents in various grades of development an essential constituent of scar-texture.

The growths composed of it contain a large proportion of gluten.

The blastema for the new growth of areolar tissue is sometimes fluid, and the development takes place according to the call-theory laws, but more often, especially when copious, it is solid and fibrinous. It exudes during the progress of protracted hyperaemiae, and in the last-mentioned form, more especially, as a consequence of inflammatory stasis. Both modes of development concur with suppuration. Moreover, extravasated fibrin, as also endogenous fibrin-coagula within the vessels furnish, under certain conditions of the fibrin, the blastema for the new formation of areolar tissue.

The chemical changes which take place during this process of development are very remarkable. They consist in numerous modifications of quantitative type, as also in qualitative differences of reaction observable in the gluten-extracts.

The time requisite for the new growth of areolar tissue varies from one to several weeks. The process of dissilience into areolar tissue fibres and fibrils, more especially in the case of copious solid blastemata, is often a very slow one.