We advert to the rare formation of variolous pustules upon the authority of other observers. We have ourselves not seen pustules in the bladder, even in cases in which the urethral mucous membrane was intensely affected by the variolous disease.

We may at the same time mention the occurrence of small millet-seed vesicles containing a clear serosity, and resembling a miliary eruption; they accompany catarrhal inflammation and slight exudative processes in the vesical, in the same manner as in other mucous membranes, and are noticed chiefly at the fundus and neck of the bladder. It is also an interesting fact that we have found them in many cases of Asiatic cholera, accompanied by painful dysuria, for which alkaline fomentations afforded considerable relief.