Ulcers or Chancres are the commonest forms of disease. The soft chancre is an ulcer which has its usual seat on the glans or frsenum. See further under Skin diseases. The hard chancre is the primary syphilitic sore, and as such has already been described.

Another syphilitic manifestation is the Condyloma, which forms a warty outgrowth sometimes of considerable size. There may be large groups of papillae forming a cauliflower-like tumour.

Gummata are very rare in the penis, but they do occur. They are stated to be in some cases the precursors of cancer.

Tuberculosis of the penis is rare, but cases are recorded in which the prepuce became infected as a result of the rite of circumcision having been performed by a person affected with tuberculosis of the lungs.

Cancer of the penis occurs in the form of epithelioma. It begins usually in the glans, and the tumour is often covered with prominent papillae, which give it a highly characteristic warty appearance, like the cauliflower excrescence. The papillae are sometimes greatly elongated like villi, so as to appear almost filiform in appearance. The tumour may remain long without ulceration, but usually sooner or later breaks down, and there are sometimes deep ulcerating fissures or fistulae. between the groups of papillae.