This, as we have seen, is a constant result of the primary syphilitic infection, and constitutes the syphilitic or Indurated bubo. The glands slowly enlarge by new-formation of round cells, and they remain enlarged for months or years. There is little caseous necrosis in the glands, but the connective tissue trabecular are thickened. During the secondary stage other glands may swell, such as those of the neck.

Gummata sometimes form in the glands in inherited syphilis and in the late tertiary stage of ordinary syphilis. There is enlargement and, it may be, extension to neighbouring glands.. The enlarged glands may or may not become caseous. (See account by Birch-Hirschfeld).