1. Syphilis

Syphilis is sometimes the cause of diffuse Interstitial nephritis. It is undoubtedly a frequent cause of Amyloid disease, and may by this means lead on to chronic nephritis. It is probable that many cases of contracted amyloid kidney have this origin. Hereditary syphilis is also believed to give rise to a diffuse interstitial nephritis.

G-ummata are very rare in the kidney. They are found in the midst of cicatrices as in the case of the liver.