Summary

Our personal experience in the experimental production of some of the so-called adaptation diseases is reviewed.

From our studies of hypertensive renal and cardiovascular disease, diabetes mellitus and neoplasms we adduce that there is no incontrovertible evidence that dysfunction of the adrenal gland is a primary cause of any of these experimental conditions.

It is true that a certain level of adrenal cortical hormone is necessary to permit the development of many of the metabolic and morphological manifestations of disease, but since this can be provided for by small constant doses of adrenal cortex extract in the absence of the adrenal gland itself, we consider that this can be regarded as an example of the permissive or supporting action of hormones.

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