(Not official.) - C6H4Ohco2h4-Och3=243.42.

Source

By the action of Phosphorus Oxychloride on a mixture of Sodium Guaiacol and Salicylate.

Characters

A white crystalline, odorless and tasteless powder. Solu-oility. - Insoluble in water; soluble in Alcohol, Ether and Chloroform.

Dose, 5 to 30 gr.; .30 to 2.00 gm.

Action and Uses of Guaiacol

External

Guaiacol is antiseptic. If painted on the skin over an area of from 4 to 20 square inches 10. to 50. sq. cm., it reduces pyrexia, but it is not used for this purpose as it causes sweating and collapse.

Internal

It is less likely than creosote to irritate the intestinal canal and kidneys. Benzosol was introduced as a nearly tasteless combination for the administration of guaiacol. In the digestive tract it splits up into guaiacol and benzoic acid. As an intestinal disinfectant it has proved to be of service in the treatment of diabetes mellitus. The carbonate and salicylate have been used as substitutes for guaiacol, and are in many cases preferable to it. Guaiacol especially the carbonate has been much given in phthisis, for it is believed to aid the destruction of the bacilli in the lungs, but although widely used there is no absolutely certain evidence that it does this. The carbonate has given excellent results in the treatment of typhoid fever in limiting the decomposition in the intestines.