The third subject was a former laboratory assistant, J. K. M. Values for eight periods, i. e., from approximately 8h30m a. m. to 12h 30m p. m., are recorded. The data for the carbon-dioxide production are given in table 41; the general average for the entire series of observations, which is shown in the last fine of the table, is 183 c.c. There is no indication of a material change in the metabolism during the forenoon, although wide variations occasionally appear from period to period. The average values for each experiment, which are given in the right-hand column, show that during the period from May 24, 1912, to July 23, 1913, or one year and two months, there was no general tendency for the carbon-dioxide production either to increase or to decrease, as the values for the most part he quite close to the general average. The chief exceptions are the minimum value of 165 c.c. on June 29, 1912, and the maximum value of 210 c.c. on May 24,1912. This latter value was obtained on the first day of experimentation, when, owing to the novelty of the situation, the metabolism is usually higher than on subsequent days.

As with the other subjects, the values for the oxygen consumption are more regular than those for the carbon-dioxide production. (See table 42.) The average for the values obtained in each period, as given at the end of the table, show a striking constancy in the metabolism throughout the day, the lowest average being 221 c.c. and the highest 227 c.c. On the other hand, the actual minimum and maximum values obtained in the individual periods show a wide variation. In the average values for the experimental days a group may be observed from June 20 to July 3, 1912, with an average of 217 c.c., and on June 5 and July 18, 1913, averages of 212 c.c. and 211 c.c. respectively were obtained. Aside from these low values no tendency is shown toward an alteration of the metabolism throughout the period of experimentation and we may fairly state that the average oxygen consumption of this subject as measured during a period of one year and two months is 225 c.c.

Table 41. - Carbon Dioxide Produced At Different Times Of Day In Respiration Experiments; Subject J. K. M., In Post-Absorptive Condition And Lying On Couch

(Values per minute.) Average age, 23 years. Average body-weight (naked), 60.4 kilograms. Height, 173 cm.

Date.

Duration of experiments.

First half hour.1

Second half hour.1

Third half hour.1

Fourth half hour.1

Fifth half hour.1

Sixth half hour.1

Seventh half hour.1

Eighth half hour.1

Average.

1912.

C.C.

c.c.

c.c.

c.c.

c.c.

c.c.

C.C.

c.c.

c.c.

May 24

8h45ma.m. to 9h58ma.m.

• • ■

204

201

224

...

...

...

...

2.0

May 28

10 00 a.m. to 11 45 a.m.

•

...

...

192

187

202

184

..

'91

June 4

8 49 a.m. to 10 30 a.m.

...

193

194

200

192

...

. ■ .

...

195

June 11

8 48 a.m. to 11 48 a.m.

178

179

.

182

172

194

18l

June 13

8 39 a.m. to 11 25 a.m.

183

178

177

185

172

185

...

...

180

June 18

8 56 a.m. to 11 41 a.m.

.

177

178

175

173

169

189

...

177

June 20

8 30 a.m. to 11 41 a.m.

175

166

177

186

179

195

181

...

180

June 26

8 51 a.m. to 11 32 a.m.

178

172

165

181

162

174

169

. ,

172

June 29

8 47 a.m. to 11 21 a.m.

164

163

176

163

152

173

164

. .

165

July 1

8 59 a.m. to 11 44 a.m.

176

...

175

159

178

169

. ..

171

July 3

9 02 a.m. to 11 49 a.m.

169

167

170

181

196

159

. .

174

July 9

9 07 a.m. to 12 01 p.m.

181

184

.

174

185

197

184

July 12

8 58 a.m. to 11 45 a.m.

174

164

176

182

176

179

170

174

July 31

10 42 a.m. to 11 58 a.m.

...

...

177

173

189

180

Sept. 20

8 43 a.m. to 11 29 a.m.

175

175

197

198

178

190

.

186

Sept. 21

8 45 a.m. to 11 36 a.m.

177

185

176

174

179

174

184

. .

178

Oct. 29

9 30 a.m. to 11 55 a.m.

■ ■ ■

198

182

181

194

191

. .

189

Oct. 30

8 57 a.m. to 12 15 p.m.

185

204

198

172

177

183

187

Oct. 31

9 04 a.m. to 12 05 p.m.

198

184

176

191

202

201

192

Nov. 19

8 55 a.m. to 10 54 a.m.

190

202

191

199

186

> ■ ■

...

194

Nov. 26

9 53 a.m. to 10 49 a.m.

...

175

178

188

...

...

180

Dec. 3

8 50 a.m. to 11 29 a.m.

180

186

181

■ • •

...

182

Dec. 12

9 35 a.m. to 11 00 a.m.

181

197

170

188

. ■ *

...

184

Dec. 14

10 16 a.m. to 10 57 a.m.

203

176

204

...

194

Dec. 15

10 07 a.m. to 10 35 a.m.

...

182

181

...

...

...

182

1913.

Jan. 23

8 58 a.m. to 11 52 a.m.

188

191

192

175

186

190

...

187

Mar. 14

8 51 a.m. to 11 27 a.m.

176

...

182

185

183

179

...

181

Apr. 29

9 38 a.m. to 11 47 a.m.

180

174

171

182

...

177

May 7

9 11 a.m. to 11 34 a.m.

180

164

181

173

185

174

176

June 5

9 11 a.m. to 12 30 p.m.

189

178

171

173

...

■ . •

200

182

July 15

9 07 a.m. to 12 11 p.m.

195

178

179

...

175

191

184

July 18

9 12 a.m. to 12 58 p.m.

...

...

185

180

172

181

...

178

179

July 23

9 37 a.m. to 12 00 p.m.

178

173

194

199

186

Days .....................

5

23

25

28

28

28

21

7

233

Minimum..........

164

163

164

163

152

169

159

170

165

Maximum...........

183

204

204

224

199

204

201

200

210

Average............,

175

181

181

185

178

183

182

187

183

M. V.............

4.8

8.1

8.7

9.8

7.7

8.0

9.1

8.7

6.3

1The experimental periods were usually 15 minutes in length and in all but one instance there was but one period in the half hour. 2The total number of periods in which the carbon dioxide was determined in the 33 experiments was 166.

Table 42. - Oxygen Consumed At Different Times Of Day In Respiration Experiments; Subject J. K. M., In Post-Absorptive Condition And Lying On Couch

(Values per minute).

Average age, 23 years. Average body-weight (naked), 60.4 kilograms. Height, 173 cm.

Date.

Duration of experiments.

First half hour.1

Second half hour.1

Third half hour.1

Fourth half hour.1

Fifth half hour.1

Sixth half hour.1

Seventh half hour.1

Eighth half hour.1

Average.

1912.

c.c.

c.c.

ex.

ex.

ex.

ex.

ex.

ex.

ex.

Ma 24

8h45ma.m. to 9h58ma.m.

...

234

237

234

...

. .

235

May 28

10 00 a.m. to 11 46 a.m.

• •

....

233

212

223

232

225

June 4

8 49 a.m. to 10 30 a.m.

• .

224

229

221

224

...

225

June 11

8 48 a.m. to 11 48 a.m.

, ,

238

230

•..•

225

227

233

231

June 13

8 39 a.m. to 11 26 a.m.

238

224

227

222

217

226

...

226

June 18

8 66 a.m. to 11 41 a.m.

241

236

233

238

231

247

238

June 20

8 30 a.m. to 11 41 a.m.

214

200

213

232

223

225

224

219

June 26

8 61 a.m. to 11 32 a.m.

222

215

217

219

216

207

223

217

June 29

8 47 a.m. to 11 21 a.m.

224

209

229

208

204

206

220

214

July 1

8 69 a.m. to 11 44 a.m.

217

...

212

205

211

227

214

July 3

9 02 a.m. to 11 49 a.m.

215

219

214

223

225

217

219

July 9

9 07 a.m. to 12 01 p.m.

236

242

227

227

233

235

233

July 12

8 68 a.m. to 11 46 a.m.

213

219

221

213

214

215

219

216

July 31

10 42 a.m. to 11 58 a.m.

• •

...

• ..

• • •

212

210

221

214

Sept. 20

8 43 a.m. to 11 29 a.m.

220

234

242

250

235

233

• •

236

Sept. 21

8 46 a.m. to 11 36 a.m.

231

244

233

235

230

233

240

...

235

Oct. 29

9 30 a.m. to 11 66 a.m.

...

236

223

227

231

236

• •

231

Oct. 30

8 67 a.m. to 12 15 p.m.

243

244

...

222

222

...

229

232

Oct. 31

9 04 a.m. to 12 05 p.m.

229

215

214

220

221

234

...

222

Nov. 19

8 55 a.m. to 10 54 a.m.

245

241

239

223

226

...

235

Nov. 26

9 53 a.m. to 10 49 a.m.

220

224

228

• • •

224

Dec. 3

8 50 a.m. to 11 29 a.m.

220

...

228

• • >

219

• • •

222

Dec. 12

9 35 a.m. to 11 00 a.m.

...

210

220

216

232

...

220

Dec. 14

10 16 a.m. to 10 57 a.m.

...

246

221

249

...

239

Dec. 16

10 07 a.m. to 10 35 a.m.

...

223

229

• ..

...

226

1913.

Jan. 23

8 58 a.m. to 11 52 a.m.

232

231

227

220

229

239

• • •

230

Mar. 14

8 51 a.m. to 11 27 a.m.

228

...

224

230

233

223

• • •

228

Apr. 29

9 38 a.m. to 11 47 a.m.

...

229

235

. .

226

223

• • •

228

May 7

9 11 a.m. to 11 34 a.m.

234

226

225

225

215

222

• • >

225

June 5

9 11 a.m. to 12 30 p.m.

213

206

207

207

• • *

226

212

July 16

9 07 a.m. to 12 11 p.m.

238

224

...

217

219

220

224

July 18

9 12 a.m. to 12 58 p.m.

...

217

216

209

209

• • •

202

211

July 23

9 37 a.m. to 12 00 m.

229

...

225

225

239

230

Days .................

5

23

25

28

28

28

21

7

233

Minimum...........

214

200

206

207

204

206

210

202

211

Maximum.............

238

245

244

246

250

249

247

239

239

Average..............

226

227

227

225

221

224

227

222

225

M. V.................

7.0

10.7

8.2

7.9

7.2

7.5

7.7

7.7

6.5

1The experimental periods were usually 15 minutes in length and in all but one instance there was but one period in the half hour. 2The total number of periods in whcih the oxygen was determined in the 33 experiments was 166.