Pancreas

Eddy, J. Biol. Chem. 27, 113, 1016-17.

Water extract contains considerable growth-promoting 8.

Williams, lb. 38, 473, 1010.

Considerable amount of growth-promoting B (yeast teat).

Dog

Swoboda, 1. c.

Exceedingly low in growth-promoting B (yeast teat).

Pineal gland, cow

Swoboda, l.c.

Fairly high in B, richer than pituitary (yeast test).

Pituitary, dog's whole

Swoboda, 1. c.

Fairly high in B (yeast teat).

Anterior lobe

Swoboda, 1. c.

Fairly high in B (yeast teat).

Pare intermedia

Swoboda, 1. c.

Fairly high in B (yeast teat).

Posterior lobe

Swoboda, 1. c.

Fairly low in B (yeast test).

Colloid

Swoboda, 1. c.

Fairly low in B (yeast teat).

Whole gland, dried

Drummond, Bioch. J. 12, 25, 1918.

Deficient in B.

Anterior lobe, dried

Drummond, Bioch. J. 12 25, 1918.

Deficient in B.

Roe, turbot

Chick and Hume, J. Roy. Army Med. Corps, 29, 121, 1917.

Alcoholic extract equivalent to 70 g. material sufficient, 35 g. insufficient to cure polyneuritie pigeon

Sciatic nerve, dog

Swoboda, 1. c.

Considerable amount of B present (yeast teat).

Suprarenal, dog

Swoboda, I.c.

Considerable amount of B present (yeast teat).

Testea

Swoboda, l.c.

Large quantities of B present (yeast teat).

Drummond, 1. c.

Deficient in B.

Thymus

Drummond, l. c

Deficient in B.

Swoboda, 1. c.

Relatively little B (yeast teat).

Glandular tissues

Thyroid

Drummond, Bioch. J. 12, 25, 1918.

Deficient in B.

Swoboda, J. Biol. Chem. 44, 530, 1920.

Considerable quantities of B present (yeast test).

Seaman, Am. J. Physiol. 53, 101, 1920.

Anttneuritic present. Acid-aloohol extract has marked accelerating action on metamorphosis of tadpoles.

Muscle tissue

Commercial extracts

Chick and Hume, quoted Hod. Res. Com. Rep. 38, p. 29.

No antineuntic present.

Powders, etc.

Osborne am Chem. 32 309, 1917; 539, 1917

Little, if any, growth-promoting B present.

Aqueous extract

Osborne and Chem. 82 309, 1917; 639, 1917

considerable growth if

Beef, raw

Cooper, J. I

Alcoholic extract equiva-

Dried

Oaborae and Mendel, J. Biol. Chem. 32, 309, 1917.

Little, if any, B present.

MEAT AND FISH (Continued)

SUBSTANCE

REFERENCE

REMARKS

Fish Muscle

Cooper, J. Hyg. 12, 436; 14,13,1914.

Little, if any, antineuritit er day afforded no protection

Cod

Drummond, J. Physiol. 62, 103, 1919.

No appreciable amount of

Herring

Drummond, J. Physiol. 52, 103, 1919.

No appreciable amount of B present.

Salmon

Drummond, J. Physiol. 52, 103, 1019.

No appreciable amount of B present.

EGGS

Eggs, whole commercial dried

Chick and Hume, quoted in Med. Ret. Com. Rep. 38, p. 29.

Equivalent of 20 g. natural egg (about 2 yolks) effective cure for polvneuritis.

Egg yolk

Cooper, J. Hyg. 14, 12, 1914.

against polyneuritis.

Boiled

McCollum and Davis, J. Biol. Chem. 23, 181. 1916.

if diet induced vigor

Yolk

Steenbock, J. Biol. Chem. 29, zxvii, 1917.

doses by intraperi-luritia.

MILK AND MILK PRODUCTS

Milk

Cooper, J. Hyg. 12. 433, 1913. Hopkins, J. Physiol. 44, 426, 1912.

Far inferior to various animal tissues as antineuritie. 35 g per day failed to give protection against polyneuritis.

Hopkins and Neville, Bioch. J. 7, 97, 1913.

2 c. c. per day or equivalent in solids to 1 to 4% of id growth.

Drummond, Bioch. J. 10, 89, 1916. Gibson and Conception, Phil. J. Sci. 11, B, 119, 1916.

B present.

in small amounts only.

Chick and Hume, J. Roy. Army Med. Corps, 29, 121.

Poor in antineuritic.

McCollum and Davis, lb. 23, 181, 1915.

As little as 2% of milk powder in the diet furnishes enough B for nearly normal growth.

Osborne and Mendel, J. Biol. Chem. 84, 637, 1918.

Leas than 24ft of dried whole milk unsatisfactory for production of good growth.

Osborne and Mendel, lb. 41, 615, 1920.

16 c. c. of fresh unpasteunsed summer milk inferior to 02 g dried brewers' yeast as source of B for growth.

Williams, lb. 46, 113, 1921.

Very poor in B (yeast test).

Butter-fit

McCollum and Kennedy, lb. 24, 491, 1916-16.

Devoid of antineuritic.

Casein, or caseinogen (unpuri-fied)

Osborne, Wakeman, and Ferry, J. Biol. Chem. 39. 35, 1919.

Almost if not completely devoid of growth-promoting B.

Casein (merck) hydrolysed

Williams, lb. 38, 473, 1919.

B absent (yeast test).

Lactalbumin

Osborne, Wakeman, and Ferry, J. Biol. Chem. 39, 35, 1919.

Practically no B retained in a preparation precipitated in acid solution.

Chick and Hume, J. Roy. Army Med. Corps, 29, 121, 1917.

Poor in antineuritic.

Cheddar

Cooper, J. Hyg. 14,12,1914.

Devoid of antineuritic.

Lactose

McCollum and Davis, J. Biol. Chem. 23, 181, 231, 1915.

Carries growth-promoting B which can only be removed by careful fractional crystallisation.

Drummond, Bioch. J. 10, 89, 1916.

Carries growth-promoting B which can only be removed by careful fractional crystallisation.

Lactose (Kahlbaum)

Williams, 1. c.

Small amount of B (yeast test).

MISCELLANEOUS

Bile, ox

Muckenfuss, J. Am. Chem. Soc. 40, 1606, 1918.

Antineuritic present, probably in small quantity.

Blood, plasma from jugular vein

Eddy and Stevenson, J. Biol. Chem. 43, 295, 1920.

B present (yeast test).

Plasma from mammary vein

Eddy and Stevenson, J. Biol. Chem. 43,295, 1920.

Richer than jugular vein (yeast test).

Feces

Osborne and Mendel, Cam. Pub. 156, pt. 2, p. 61.

Rats declining on a vitamin-free diet improved when fed small quantities of feces from rats on normal diet.

Cooper, J. Hyg. 14, 12, 1914.

Antineuritic present.

Saliva

Muckemuss, 1. c

Useless as a preventive, but seemed to have some curative power for polyneuritis.

Funk and Dubin, J. Biol. Chem. 44, 487, 1920.

No B present (yeast test).

Urine

Muckenfuss, 1. c.

Antineuritic apparently present in traces in fresh human urine.

Qagho, Polyclinico, 26, 1381, 1919.

Pronounced polyneuritis cured by small amounts of human urine.

Curatolo, lb. 27, 439, 1920.

Confirms Goglio, using rabbit urine. Potency apparently restricted to nitrogenous waste in the urine.

Funk and Dubin, 1. c

B present (yeast test).

LEAFY VEGETABLES AND GRASSES

SUBSTANCE

REFERENCE

REMARKS

Alfalfa

McCollum, Simmonds, and Pits, Am. J. Physiol. 41, 333.

B present.

Osborne and Mendel, J. Biol. Chem. 41, 4S1, 1920.

Alfalfa surpasses all other products known, except clover (and possibly tomatoes) in growth-promoting power. 1 g. per day (10 to 15% of food intake) produced extraordinarily good growth.

Steenbock and Grose, lb. 41, 149, 1930.

10% in diet insufficient. 15% sufficient to induce normal growth.

Williams, lb. 46, 113, 1921.

Less than half the value of brewers' yeast (yeast test).

Cabbage, juice

McCollum and Kennedy, J. Biol. Chem. 24, 491, 1916-16.

Antineuritic present, though not in very large amounts.

Chick and Hume, Tr. Soc. Trop. Med. Hyg. 10, 141, 1916-17.

Antineuritic present in rather low concentration as compared with whole wheat.

Osborne and Mendel, J. Biol. Chem. 41, 451, 1920.

Comparable to spinach in growth-promoting power.

Steenbock and Grow, lb. 41, 149, 1930.

15% in diet furnishes sufficient B to promote normal growth.

Williams, lb. 46, 113, 1931.

Each (yeast test).

Etiolated leaves

Delf, S. Af. J. Sci. 17, 121, 1920.

Clover

Osborne and Mendel, 1. c.

Steenbock and Gross, 1. c.

sufficient for normal

"Greens"

Chick and Hume, Med. Res. Com. Rep. 38, p. 30.

20 g. of material com-pigeon.

Spinach, dried at 50 to 60o

Osborne and Mendel, J. Biol. Chem. 37, 187, 1919; 41, 4S1, 1920.

as dried yeast, one-id twice as efficient as whole wheat, dried eggs,or milk solids in promot-

. daily (10 to 15% of t for growth.

Williams, lb. 46, 113, 1921.

ue of brewers' yeast (yeast test).

Timothy hay

Osborne and Mendel, lb. 41, 451, 1920.

Apparently potent in promoting growth in earlier periods of experiment, but disappointing in the long run.

CEREAL GRAINS AND SEEDS

Barley, unhausked

Cooper, J. Hyg. 12, 430; 14, 13.

Contains antineuritic.

Chick and Hume, Med. Res. Com. Rep. 38, p. 38.

3.7 g. per day added to polished rice diet protected pigeons against polynutritis.

Husked

Chick end Hume, Med. Res. Com. Rep. 38, p. 28.

5.C g. per rice diet protected pigeons against polyneuritis.

Steenbock, Kent, end Gross, J. Biol. Chem. 36, 61, 1918.

normal growth wth, no young

Osborne and Mendel, lb. 41, 276,1890.

46% in diet furnished sufficient B for normal growth.

Pearled

Osborne end Mendel, lb. 41, 276, 1920.

73% in diet furnished sufficient B for normal growth.

Beans,string commercial,

Davis, J. Home Ec 13, 209, 1930.

10 g. per day afforded no protection, but if supplemented by 2 g. raw corn gave complete protection against polyneuritis.

Soy

Daniels end Nichols, J. Biol. Chem. 33, 91, 1917.

Liberal amount of growth-promoting B present.

Osborne and Mendel, Proc. 600. Exp. Biol. Med. 14, 174. 1917.

Equivalent to milk in growth-promoting power.

Johns and Finks, Am. J. Physiol. 66, 466, 1931.

16% soy bean flour and 86% wheat flour gave ample B for growth.

Oil

Fahricn, Chem. Umscbau. 37, 97,109,1930.

Pressed oil may contain vitamin, oil extracted with solvent little or none.

White

MoCollum, Simmonda, and Pita, J. Biol Chem 29, 621, 1917.

25% in the diet furnishes sufficient B for normal growth and reproduction.

Voegtlin, Lake, and Myers, U.S Pub. Health Repta. 33, 047, 1918.

Concentrated preparation of antineuritic can be obtained.

Con (see maize)

Cottonseed floor

Osborne and Mendel, Proc. Soc. Exp. Biol.

Med. 13, 147. 1916. Richardson ana Green, J. Biol. Chem. 31,

379, 1917.

Equivalent to milk in growth-promoting power.

ralent to 60% of Sour in the ient B for normal growth for

Maizekernel

Funk, Bioch. Bull. 6, 1, 1913.

probably distributed in ex-

Voegtlin, Lake, and Myers, U.S. Pub.

Health Repa. 33. 047. Green, a Af. J. Sci. 14, 619, 1018.

16 to 30 g. per day supplied sufficient B for prevention of polyneuritis. 80% more antineuritic than required in metabolism.

CEREAL GRAINS AND SEEDS (Continued)

SUBSTANCE

REFERENCE

REMARKS

Endosperm

Funk and Dubin, J. Biol. Chem. 44, 487, 1920.

B present (yeast test).

Degerminated

Voegtlin and Myers, J. Biol. Chem. 41, x, 1920.

Practically devoid of antineuritic.

Germ

Chick and Hume, Proc. Boy. Soc. 90B, 44, 1917.

potency present in both scutel-1 to 3 g. effected cure of poly-

Germ, commercial

McCollum, Simmonde, and Pits, J. Biol. Chem. 23, 153 1910-17.

i present in abundance.

Germ, alc. ext.

Voegtlin and Myers, J. Biol. Chem. 41, z, 1920.

Effective antineuritic.

Bran

Voegtlin, Lake, and Myers, 1. c.

10 g. set of polyneuritis.

Green, 1. c.

80% antineuritic than required in

Grits, highly milled

Voegtlin, Lake, and Myers, 1. c.

15 to

Meal, old process water ground

Voegtlin, Lake, and Myers, 1. c.

10 g not

Fine meal

Green, 1. c.

20% more antineuritic than required in metabolism.

Seconds

Green, 1. c.

70% more antineuritic than required in metabolism.

Hominy

Voegtlin, Lake, and Myers, 1. c.

15 to polyneuritis.

Hominy chop.

Green, l. c.

Very

Hominy samp.

Green, l.c.

Very poor in antineuritic

Starch

Osborne, Wakeman, and Ferry, J. Biol. Chem. 39, 36, 1919.

No appreciable quantity of growth-promoting B.

Oats

McCollum and Kennedy, J. Biol. Chem. 24, 491, 1915-16.

Pigeon cured of polyneuritis and kept in good condition by ag. ext. of 24 g. rolled oats per day.

McCollum, Simmonda, and Pits, lb. 29, 341, 1617.

Oat kernel contains a liberal supply of B.

Osborne and Mendel, lb. 41, 283, 1920.

35.5% of oat kernels in the diet furnish sufficient B for normal growth.

Peas, dried

Chick and Hume, Med. Res. Com. Rep. 38, p. 30.

10 g. effected complete cure of polyneuritic pigeon.

Vedder and Clark, Phil. J. Sci. 7B, 433.

10 g. daily protects fowls on polished rice diet from polyneuritis for at least 90 days.

McCollum, Simmonds, and Parsons, J. Biol. Chem. 37, 287, 1919.

6% in diet failed to protect rata against polyneuritis. (Compare with wheat germ, of which 2% is sufficient).

Cow

Sullivan and Voegtlin, J. Biol. Chem. 24, xvi, 1915-18.

Antineuritic present.

Rice, unhusked

Gibson and Coocepcion, Phil. J. Sci. 9B, 119, 1914.

afforded incomplete protection against as shown by degenerative changes of

McCollum and Davis, J. Biol. Chem. 23, 206, 1915.

whole wheat. 88% in the diet fur-nt B for normal growth.

Polished

Anat. 148, 623, 1897;

Devoid of antineuritic.

68, 150, 1906.

nd Oake, Bioch. Z.

13, 135, 1913.

Rice polishings

Eijkman, Arch. path. Anat. 148, 623, 149, 187, 19S7.

Antineuritic present.

Fraser and Stanton, Phil. J. Sci. 5B, 55, 1910.

Chamberlain and Vedder, Phil. J. Sci. 6B, 251, 396, 1911.

1911-12.

Odake, Bioch. Z.

upaon, and Web-2.

Cooper, lb. 7, 268, 1912-13.

Strong and Crowell, Tr. 16th Int. Cong. Hyg. 5, 670, 1913.

Drummond and Funk, Bioch. J. 8, 698, 1914.

Chick and Hume, Med. Res. Com. Rep. 38, p. 29.

6g. failed, 10 g. sufficed to cure polyneuritic pigeon.

Bran

Chide and Hume, Proo. Roy. Boo. 903, 44, 1817.

Antineuritic present, probably in aleurone layer, but to lees degree than in germ.

Germ

Chick and Hume, Proo. Roy. Soc. 90B, 44, 1917.

Antineuritic of rice grain concentrated in germ.

CEREAL GRAINS AND SEEDS (Continued)

SUBSTANCE

REFERENCE

REMARKS

Chick and Hume, Med. Res. Com. Rep. 38, p. 29.

0.5 to 1 g. sufficient to cure polyneuritic pigeon.

Eye

Hoist, J. Hyg. 7, 629, 1907. .

Antineuritic present.

Osborne and Mendel, J. Biol. Chem. 41, 276, 1920.

40% in diet appears to furnish sufficient B for growth.

Seeds of plants, cereals, and pulses

Chick and Hume, J. Roy. Army Med. Corps, 39, 121, 1917.

Principal sources of antineuritic.

McCollum, Simmonds, and Pita, J. Biol. Chem. 30, 13, 1917.

Growth-promoting B abundant.

Tomatoes-seed press-cake

Finks and Johns, Am. J. Physiol. 56, 404, 1921.

Can serve as sole source of B.

Wheat, kernel

Chick and Hume, Proc. Roy. Boo. 90B, 44, 1917.

Antineuri and present to less degree in aleurone layer.

McCollum, Simmonds, and Pita, J. Biol. Chem. 28, 211, 1916-17.

15% in diet furnished sufficient B for growth and almost normal reproduction. but not sufficient to

Osborne and Mendel, lb. 41, 275, 1920.

adequate amount

Endosperm

Osborne and Mendel, 7b. 37, 657, 1919.

Voeotlin, Lake, and Myers, lb. 41, x, 1990.

Funk and Dubin, 7b. 44, 487, 1920.

Determinated

Voegtlin and Myers, lb. 41, x, 1920.

Degerminated carefully by

Osborne and Mendel, 37, 667, 1919.

As efficient as whole wheat in inducing growth.

Germ

McCollum and Davis, J. Biol. Chem. 23, 181, 1916.

Hot water extract of 6 g. wheat germ per 100 g. of ration induced vigorous growth.

McCollum, simmonds, and Pita, 7b. 26, 106, 1916.

2% in diet furnishes sufficient B for growth.

Chick and Hume, Proc. Roy. Soc. 90B, 44, 1917.

3 in

Commercial

Osborne and Mendel, J. Biol. Chem. 37, 667, 1919.

R B.

Carefully separated by hand

Osborne and Mendel, J. Biol. Chem. 37, 557, 1919.

155 mg. per day suffices to maintain young rats, but will not induce growth.

Funk and Dubin, 7b. 44, 487, 1930.

Ten times as potent as endosperm (yeast test).

Alc. ext

Voegtiin end Myers, J. Biol. Chem. 41, x, 1020.

Relieves symptoms of polyneuritis.

Ala. ext

Williams, 7b. 38, 473, 1919.

Considerable B (yeast test).

Wheat, bran

Sullivan and Voegtlin, J. Biol. Chem. 24, xvi, 1916-16.

Pprepared concentrated extract of antineuritie B from

Chick and Hume, Med. Res. Com. Rep. 38, p. 28.

protection against polyneuritis. delayed onset of disease about 2 weeks.

Comercial

Osborne and Mendel, J. Biol. Chem. 37, 557, 1919.

5% in diet insufficient for growth of mini or maintenance of adult sufficient. Much leas germ.

Flour

Whole wheat

Simpson and Edie, Ann. Trap. Med. Par-aefl. 6, 321. 1911-12.

Antineuritie present

Wellman and Bass, Am. J. Trap. Die. Prev. Med. 1918.

Antineuritie present in "whole wheat" but lacking in patent flour.

Voegtlin, Lake, and Myers, U. S. Pub. Health Rep. 33, 047, 1918.

Exclusive diet protects against polyneuritis.

Whole wheat breed

Ohler, J. Med. Res. 31, 238.

Antineuritie present.

Graham

Voegtlin, Lake, and Myers, 1. c.

against polyneuritis.

Flour from buhr mill

Voegtlin, Lake, and Myers, 1. c.

hole wheat but more than

Patent floor

Hoist, J. Hyg. 7, 620, 1907.

Deficient in antineuritie.

Simpson and Edie, Ann. Trap. Med. Pans. 6, 321, 1911-12.

Deficient in antineuritie.

Ohler, 1. c.

Deficient in antineuritie.

Chick and Hume, J. Roy. Army Med. Corps, 29, 121,1917.

Deficient in antineuritie.

Voegtlin, Lake, and Myers, 1. c.

No protection against polyneuritis.

Osborne and Mendel, I.c.

Much poorer than commercial germ in growth-promoting power.

TUBERS AND ROOTS

Beets

Osborne and Mendel, J. Biol. Chem. 30, 20, 1010; 41, 461, 1020.

Less growth-promoting power than other common roots.

Considerable quantities of B present in stem and leaves.

Williams, lb. 40, 118, 1021.

Poor in B (yeast test).

TUBERS AND ROOTS (Continued)

SUBSTANCE

REFERENCE

REMARKS

Sugar

Steenbock and Gross, lb. 40, 501, 1919.

26% in diet furnished insufficient amount of B for growth.

Carrots

Chick and Hume, Tr. Soc. Med. Hyg. 10, 141, 1916-17.

Rather poor as antineuritic. About equivalent to fresh meat.

Suguira and Benedict, J. Biol. Chem. 36, 171, 191, 1918.

carrots cure more slowly.

Steenbock and Gross, lb. 40, 501, 1919.

permit good growth.

Osborne 41, 461, 1920.

Comparable to spinach.

Davie, J. 09, 1920.

5 g. per day gave no protection against polyneuritis.

Williams, J. Biof Chem. 46, 113, 1921.

About, one-fifth value of brewers' yeast (yeast test).

Canned

Davis, J. Home Ec. 12, 209, 1920.

10 g. per day gave some protection against polyneuritis.

Alc ext.

Zilva, Bioch. J. 14, 494. 1920.

Antineuritic present

Dasbeen

Steenbock and Gross, I. c.

16% in diet supplied sufficient B for growth.

Mangel

Steenbock and Gross, 1. c.

26% in diet did not supply sufficient B for growth.

Chamberlain, Vedder and Williams, Phil. J. Sci. 7B.45, 1912.

Ag. ext. without effect on polyneuritic pigeons.

Chick and Hume, Tr. Soc. Med. Hyg. 10, 141, 1910-17.

Rather poor as antineuritic. About equivalent to fresh meat.

Davis, 1. c.

10 g. per day equivalent to 8 g. boiled or baked potato as antineuritic.

Osborne and Mendel, J. Biol. Chem. 39, 29, 1920.

Considerable growth-promoting B present.

Potato (raw or cooked)

Vedder and Clark, Phil. J. Sci. 7B, 6, 1913.

polyneuritis to diet.

Juice

Vedder and Clark, Phil. J. Sci. 7B, 6, 1912.

McCollum and Kennedy, J. Biol. Chem. 24, 491, 1916-16.

improvement in

Peel

Chick and Hume, Med. Res. Com. Rep. 38, p. 30.

fresh peelings ment but failed to cure polyneuritic pigeon.

Peeled

Chick and Hume, Med. Res. Com. Rep. 38, p. 30.

Alc. extract equivalent to 360 g. of fresh material cured a polyneuritic pigeon.

Cooked

McCollum, Simmonda, and Parsons, J. Biol. Cbem. 36, 197,1918.

84.5% in diet furnished enough B for growth of young rats.

Peeled, dried

Osborne and Mendel, J. Biol. Cbem. 41, 451, 1920.

Comparable to turnip, carrot, etc. 2 g. daily did not promote normal growth.

Feel

Osborne and Mendel J. Biol. Cham. 41, 461, 1930.

No richer in growth-promoting B than corresponding quantities of whole potato.

Rmw

Davis, J. Home Ec 12, 309, 1920.

8 per day protected pigeons against polyneuritis

Cooked

Davis, J. Home Ee. 12, 309, 1920.

N potato in antineuritic power.

Dried (oom).

Davie, J. Home Ec. 12, 209, 1930.

2 g. per day gave no protection, 4 g. at least partial protection against polyneuritis.

Dried

Williams, J. Biol. Cbem. 46, 113, 1931.

Less than one-third value of brewers' yeast. Equivalent to cabbage (yeast test).

Turnip, dried

Osborne and Mendel, J. Biol. Chem. 39, 29, 1919; 41, 451, 1920.

growth-promoting B.

Williams, lb. 49, 113, 1920.

About one-sixth value of brewers' yeast (yeast test).

Rutabagas

Steenbock and Gross, lb. 40, 501, 1919.

15% in diet sufficient to induce normal growth.

FRUITS

Apples

Osborne and Mendel, J. Biol. Chem. 42, 486, 1920.

Some, but not much, growth-promoting B.

Banana.

Loeb and Northrop, lb. 27, 309, 1916.

Probably deficient in growth-promoting B.

Suguira and Benedict, lb. 36, 171, 1918.

Deficient in growth-promoting B.

Currants, dried

Chick and Hume, Med. Res. Com. Rep. 38, p. 30.

Alcoholic extract apparently devoid of antineuritic power.

Dates, dried

Chick and Hume, Med. Res. Com. Rep. 38, p. 30.

Alcoholic extract corresponding to 26 g. of fruit brought about slight temporary improvement in polyneuritic bird.

Grape juice, commercial

Davis, J. Home Ee. 12, 209, 1920.

3 g. daily gave no protection against polyneuritis.

Osborne and Mendel, I. c

Far leas efficient than orange juice as a growth stimulant.

Grapefruit juice

Osborne and Mendel, I. c,

Growth-promoting properties about equivalent to orange juice or milk.

Lemon juice

Osborne and Mendel, 1. c.

10 c. c. per day insufficient for growing rats. About equivalent to orange juice in growth-promoting power.

FRUITS (Continued)

SUBSTANCE

REFERENCE

REMARKS

Lime juice

Funk, Bioch. J. 7, 81, 1913.

Antineuritie present.

Orange juice

Harden and Zitva, lb. 12, 93,1918.

Antineuritic present in very snail amounts.

Byfield, Daniels and Loughlin, Am. J. Dis. Child. 19, 349, 1920.

75 c. c. orange juice per 100 g. of food promotes mammal growth, 55 c. c. does not.

Osborne and Mendel, J. Biol. Chem. 42, 466, 1920.

Fresh juice about equivalent to milk in growth-promoting power.

Feel

Osborne and Mendel, J. Biol. Chem. 42, 466, 1920.

5 g. per day efficacious as growth stimulant

Pears

Osborne and Mendel, J. Biol. Chem. 42, 465, 1920.

Some, but not much, growth-promoting power.

Prunes

Osborne and Mendel, J. Biol. Chem. 42, 465, 1920.

Contain B than apples or pears, though probably not very rich.

Raisins

Davis, J. Home Ec. 12, 209,1920.

3 g. per day insufficient, 8 g. sufficient to give protection against polyneuritis.

Tomato

Osborne and Mendel, J. Biol. Chem. 39, 29, 1919.

Rich in growth-promoting B.

Canned

Osborne and Mendel, J. Biol. Chem. 39, 29, 1919.

1 g. daily furnished enough B to promote good growth, even 0.2 g. occasionally produced limited growth or, at least, maintenance.

Williams, lb. 46, 113, 1921.

Leas than one-sixth the value of brewers' yeast (yeast test).

Nuts

Almond

Cajori, J. Biol. Chem. 43, 683, 1920.

Normal growth when B was supplied by 2 g. of almonds daily. 1 g. leas effective than OS g. of pecan or chestnut.

Brazil nut

1 g. induces normal growth, 0.6 g. permits slow growth.

Chestnut

1 g. induoes normal growth, 0.5 g. permits slow growth.

Coconut press-cake

Johns, Finks, and Paul, lb. 37, 497, 1919.

Induced satisfactory growth as sole Bourse of B.

Filberts

Cajon, 1. c.

Equivalent to almond.

Hickory

Cajori, 1. c.

1 g. daily induced renewed growth in animals declining for lack of B.

NUTS AND MISCELLANEOUS

Peanut

Vedder and Clark, Phil. J. Sci. 7B, 1, 1912.

10 g. per day protects fowls on polished rice diet against polyneuritis for at least 60 days.

Daniels and Longhlin, J. Biol. Chem. 83, 295, 1918.

58% in ration gave sufficient B for normal growth of rats.

Griei, 2nd J. Med. Res. 6, 143, 1918.

Rich in antineuritie.

Pecan

Cajori, J. Biol. Chem. 43, 583, 1920.

1 g. gives 0.5 g. permits of partial recovery in anunasi which have declined

Pins-nut

Cajori, J. Biol. Chem. 43, 383, 1920.

1 g. daily induced recovery of animals which had declined for lack of B.

Walnuts, black

Cajori, J. Biol. Chem. 43, 383, 1920.

Equivalent to chestnuts.

English

Cajori, J. Biol. Chem. 43, 683, 1920.

2 g. daily gives normal growth.

MISCELLANEOUS

Beer

Hoist, Centr. f. Bakt, Mar. 27, 1918.

Useful as curative substance in treatment of beriberi.

Coffee (roasted)

Di Mattei, Policlin. 27, 1011, 1990.

Polyneuritic pigeons cured temporarily but not permanently by coffee infusion. Probably not fame vitamin present.

Crisco (autoclaved for 3 hours)

Funk and Dubin, J. Biol. Chem. 44, 487, 1920.

No B present (yeast test).

Honey

Duteher, lb. 35, 661, 1918.

Traces of antineuritic present (possibly due to pollen grains).

Malt extract

Hawk, Smith and Bergeim, Am. J. Physiol. 63, 839, 1921.

Not more than miaimal amount of B in strained honey.

Cooper, J. Hyg. 14,12,1914.

Two samples very efficient as antineuritie, while third was inactive.

Van der Widen, Phann. Weekblad. 62, 673, 1916.

Can be used for preparation of antineuritic extract.

Nectar

Duteher, 1. c.

No antineuritic present.

Pollen (earn)

Dutoher, 1. c.

Relatively rich in antineuritic.

Yesst, autolysed

Chamberlain and Vedder, Phil, J. Sci. 6B, 396, 1911.

Antineuritic present.

Cooper and Funk, Lane. 1911, ii, 1268.

Edie, Evana, Moore, Simpson and Webster, Bioch. J. 6, 234, 1912.

Cooper, J. Hyg. 12, 436; 14, 12, 1914.

MISCELLANEOUS (Continued)

SUBSTANCE

REFERENCE

REMARKS

Funk. Bioch. Bull. 6, 1, 1916.

Richer in antineuritic than any known foodstuff.

Seidell, 1. Biol. Chem. 29, 145, 1917.

05 to 1 c. c. of filtrate just sufficient to replace deficiency of polished rice.

Voegtlin, Lake, and Myers, U. S. Pub. Health Hep. 33, 047, 1918.

Chick and Hume, Med. Res. Com. Rep. 38, p. 30.

2 g. induced slow cure in polyneuritic pigeon.

Hoist, J. Hyg. 7, 629, 1907.

Delays symptoms of polyneuritis, but not lose of weight.

Fresh

Hopkins, J. Physiol. 44, 426, 1912.

Good source of antineuritic.

Funk, J. Biol. Cbem. 27, 1, 1916.

Funk and Macallum, lb. 23, 413, 1915; 27, 51, 1916.

Osborne and Mendel, lb. 31, 149, 1917; 41, 451, 1920.

Richest of all substances tested in growth-promoting power.

Seidell, lb. 29, 145, 1917.

Less effective than autolyted.

Extract Commercial

Chick and Hume, Med. Ret. Com. Rep. 38. p. 30.

1.5 to 2 g. effected complete cure in polyneuritic bird.

Voegtlin, Lake, and Myers, U. S. Pub. Health Rep. 33, 647, 1918.

Addition to bread in amounts used by bakers does not prevent polyneuritis but retards onset slightly.

Extract, brewers'

Williams, J. Biol. Chem. 46, 113, 1921.

Very rich (yeast test).

Marmite. commercial preparation of yeast

Willcox, Lane. 1919, ii, 979.

Used as prophylactic in beriberi.

HEAT AND FISH

Beef, dried

Pits, J. Biol. Chem. 36, 439, 1918.

5% in diet of rolled oats with milk ad lib. did not delay onset of life of animal.

Givena and MoClugage, Set. 51, 273, 1920.

Freeh raw

Dutcher, Pieraon, and Blester, J. Biol. Chem. 42, 301, 1920.

Frozen

Wiltshire, Lane. 1918, ii, 811.

Poor in C.

Comrie, Edin. Med. J. 24, 207, 1920.

Scurvy developed on a diet including seven and one-quarter os. per day of frosen or tinned meat or tut herring.

Fish muscle

Parsons, J. Biol. Chem. 44, 589, 1920,

C absent or very low.

Baited salmon

Koga, Bul. Naval Med. Ax. Tokyo, 1920, p. 2.

No protection.

Liver, beef

Parsons, J. Biol. Chem. 44, 6S9, 1920.

High in C.

Pig

Parsons, J. Biol. Cbem. 44, 689, 1920.

High in C.

Rat

Paraona, J. Biol. Chem. 44, 589, 1920.

High in C.

Bad

Hoist, 15th Int. Cong. Eyg. Wash. 1912, ii, 588.

Used by Eskimos as remedy for scurvy.

Cod oil

Cohen and Mendel, J. Biol. Chem. 35, 443, 1918.

1 c. e. daily gave no protection against scurvy.

Hess and linger, lb. 35, 479, 1918.

0.5 to 1 c. c. gave guinea pigs, nor is it effective in

Meat, fresh raw

Barlow, Lane. 1894. ii, 1075.

Less antiscorbutic or vegetables.

Willow, Lano. 1917, ii, 677; 1919, ii, 979.

Valuable antiscorbutic.

Stevenson, J. Roy. Army Med. Corps, 35, 218, 1920.

Distinct antiscorbutic value.

(Bat muscle)

, c.

Salt pork

Koga, 1. c.

Juice, raw

Chick, Hume, and Skelton, Lane. 1919, ii, 322.

ve slight protection against scurvy

Cooked

Barlow, Lane. 1894, ii, 1075.

Recommended as antiscorbutic for infants.

Extract

Dutcher, Pieman, and Bieeter, J. Biol. Chem. 42, 301, 1920.

No demonstrable antiscorbutic present.

MILK

Milk, fresh

Curran, Dub. J. Med. Sci. 7, 83, 1847.

1 pt. of milk daily insufficient to protect adults from scurvy on diet deficient in fresh meat and vegetables.

Barlow, Lane. 1804, ii, 1075.

Less effective antiscorbutic than fresh vegetables or fruits.

Funk, J. Biol. Cbem. 25, 409, 1916.

50 c. c. daily gave protection to guinea pigs on a diet

Jackson and Moore, J. Infect Die. 19, 478, 1910.

Milk fed ad lib. afforded no protection to 30 out of 41 guinea pigs.

Chick, Hume, and Skelton, Bioch. J. 13, 131, 1918; Lane. 1918, i. 1.

85 to 135 c. c. daily gave complete protection against scurvy for about three months; on 30 to 50 c. c. death from scurvy occurred in about 30 days.

Cohen and Mendel, J. Biol. Chem. 35, 438, 1918.

Small quantities of milk ineffective, large amounts gave practically complete protection against aeurvey.

MILK (Continued)

SUBSTANCE

REFERENCE

REMARKS

Drummond, Lane. 1918, ii, 482.

Little antiscorbutic present.

Barnes and Hume, Bioch. J. 13, 306, 1919.

Guinea pigs on diet of oats and bran require 100 to 150c.c. for protection; monkeys of 2 to 8 kg. body weight require 126 to 176 c. c.

Hart, Steenbock; and Smith, J. Biol. Chem. 38, 305, 1919.

47 c. c per day added to rolled oats diet will not prevent scurvy in guinea pigs; 84 c. c. per day added to diet of oats and hay gives absolute protection.

Hen and Unger, lb. 38, 203, 1910.

80 c. c daily cured scurvy.

Sour

Comrie, Edin. Med. J. 24, 307, 1820.

More effective than lemon juice for treatment of human scurvy.

Stevenson, J. Roy. Army Med. Corpe, 36, 218, 1920.

Sour milk and lemon juice added to ordinary diet best cure for human scurvy.

Condensed

Davis, J. Home Ec. 12, 209, 1920.

76 c. c. per day allowed onset of scurvy in 4 weeks.

Hart, Steenbock, and Smith, J. Biol. Chem. 38, 305, 1919.

3S to S3 c. c per day allowed onset of scurvy in 80

Milk, dried (Just-Hatmaker process)

Barnes and Hume, Bioeh. J. 13, 306, 1919.

300 c. c fluid milk required to ded by 150 to 175 c. c. of fresh

Hart, Steenbock, and Smith, J. Biol. Chem. 88, 393, 1919.

lue in some specimens at least, 45 c. c. fluid milk allowed de-f in 5 to 6 weeks; on 76 to 90 for 5 to 15 weeks.

(Just-Hatmaker)

Hess and Unger, J. Biol. Chem. 38, 293, 1919.

fresh milk Cures infantile survy.

Hopkins, Lane. 1919, ii, 979.

Infants do not develop scurvy on a diet of dried milk.

(Just-Hatanaker)

Davis, J. Home Ec. 12, 209, 1930.

Equivalent of 160 c. c. fluid milk gave complete protection to guinea pigs.

Butter

Cohen and Mendel, J. Biol. Chem. 36, 433, 1918.

No antiscorbutic demonstrable.

MISCELLANEOUS

Egg, whole

Hess and Unger, J. Biol. Chem. 86, 479, '. 1918.

Failed to delay onset of scurvy in guinea pigs, nor was it effective in treatment of infantile scurvy.

LEAFY VEGETABLES AND GRASSES

Cabbage, dried at high tern-peratura

Hoist and Frolich, Ztsohr. Hyg. 73,1, 1913.

No antiscorbutic present.

Dried at 37o

Hoist and Frolich, Zteohr. Hyg. 73, 1, 1913.

due after 6 mce. storage in in-

Chick and Rhodes. Lane. 1918, ii, 774.

1 guinea pigs.

Cohen and Mendel, J. Biol. Chem. 36, 43S, 1918.

ted guinea pigs on soy bean per day added to diet of oats permits successful reproduction.

Dried at 70 to 80*

Cohen and Mendel, J. Biol. Chem. 36, 438, 1918.

1 g. and 80 c. c. of milk daily maintained guinea pig in excellent condition, 3 g. per day cured scurvy that had developed on soy bean cracker diet.

Raw

Givena and Cohen, lb. 30, 127, 1918.

10 g. per day eives complete protection to guinea also initiates prompt recovery provided disease has not gone too far.

Dried at Off to 78*

Givena and Cohen, lb. 30,137,1918.

1 to 2 g. per day gives no protection.

Dried at 65 to 78o and cooked

Givena and Cohen, lb. 30, 127, 1918.

Equivalent of 10 g. raw gave no protection.

Dried at 42 to 52o

Givena and Cohen, lb. 30, 137, 1918.

1 g. per day delayed onset of disease and prolonged

Fresh

Chick, Hume, and Skeltcm, Lane. 1919, ii, 322.

1.6 g. per day minimum dose affording protection.

Delf. quoted by Campbell and Chick, lb. 321.

0.5 g. per day partial protection, 1.5 g. complete protection on diet of oats, bran, and autoclaved milk.

Freeh cooked 60 at 90o

Delf. quoted by Campbell and Chick, Ib. 331.

5 g. per day gave no protection.

Cooked 20' at 100o

Delf. quoted by Campbell and Chick, lb. 331.

5 g. per day gave almost complete protection.

Canned, 60' at 90 to 100o

Delf. quoted by Campbell and Chick, lb. 321.

5 g. per day gave partial protection in 3 out of 3 cases, 7.5 g. per day gave complete protection.

Fresh

Davis, priv. com. 1920.

7 g. per day kept guinea pigs in good condition for 386 days. On 5 g. they lost weight, which was regained when they were returned to the 7 g. ration.

Dandelion

Hoist and Frolich, Ztsch. Hyg. 72, 1, 1913: 76, 334, 19B.

Antiscorbutic when fresh, but lose power completely on drying.

LEAFY VEGETABLES AND GRASSES (Continued)

SUBSTANCE

REFERENCE

REMARKS

Hay

Hose and Unger, Proc. Soc. Ezp. Biol. Med. 15, 82, 1918.

Valuable as roughage, but did not prevent scurvy when added to oats and water diet.

Cohen and Mendel, J. Biol. Chem. 35, 433, 1918.

No antiscorbutic present.

Baraea and Hume, Bioch. J. 13, 306, 1919.

Probably not devoid of antiscorbutic, amount varying with age of bay.

Hart, Steenbock, and Smith, J. Biol. Chem. 38, 305, 1919.

Leas milk required for protection of guinea pigs against scury when hay forma part of diet.

Rhubarb

Curran, Dublin J. Med. Sci. 1847, 7, 83.

Piereon and Dutcher, Sci. 51, 70, 1920.

Guinea pi 'ceding rhubarb, raw or after 15 minutes cooking.

Spinach, canned

Davis, priv. com. 1920.

Great variation in different lota of commercial canned spinach. Complete protection in same cases, poor in others.

CEREAL GRAINS AND SEEDS

Barley, whole

Cohen and Mendel, J. Biol. Chem. 35, 425, 1918.

Scurvy develops rapidly on exclusive diet of barley.

Germinated

Weill, Cluset, and Mouriquand, C. r. Soc.

Biol. 70, 36, 1917. Cohen and Mendel, 1. c.

Better than ungenninated grain as complete food for Kuinea pigs.

on exclusive diet of

Beans, dried Geminated

Davie, priv. com. 1920. Wiltshire, Lane. 1918, ii, 811. Comrie, Edin. Med. J. 1920, 207. Stevenson, J. Roy. Army Med. Corps, 36, 218, 1020.

eu.

for cure owing to

Red, germinated

Koga, Bui. Naval Med. Am. Tokyo, 1920, p. 2.

20 g. per day gave protection to guinea pigs for 41

String, fresh raw

Campbell and Chick, Lane. 1919, ii, 321.

5 g. per day afforded no protection.

Cooked 140' at 100o

Campbell and Chick, Lone. 1910, ii, 321.

20 g. per day afforded no protection.

Chick, Hume, and Skelton, lb. 1919, ii, 774.

5 g. per day minimum dose giving protection.

Davis, priv. com. 1920.

Great variation in different specimens. Litter of guinea pigs successfully raised on 30 g. per day.

String, canned

Davis, priv. com, 1090.

15 g. daily delayed but did not prevent onset of scurvy.

Soy flour

Heated at 120 for 30

Cohen and Mendel, J. Biol. Chem. 36, 435, 1918.

No antiscorbutic present.

Cereals, dry

Furat, Z. Hyg. Infekt. 73, 131, 1913.

Antiscorbutic power lacking, but present after germination.

Chick and Hume, J. Roy. Army Med. Corps, 29, 121, 1917.

No C present.

Germinated

Chick and Hume, J. Roy. Army Med. Corps, 29, 121, 1917.

Antiscorbutic power appears with beginning of active cell life.

Weill, Mouriquand, and Peronnet, C. r. Soc. Biol. June 8th, 1918.

Question the efficacy of sprouted cereals as antiscorbutic.

McClendon, Cole, Engstrand and Middle-kauf, J. Biol. Chem. 40, 243, 1919.

Rich in antiscorbutic, especially when acrospire projects 05 in beyond grain.

Corn, (see maize)

Maize, germinated

Furst, Nord. Med. Arch. Abt. ii, 1910. Supp. 349.

Freeh sprouted com antiscorbutic, but dried corn, whether germinated or not, without protective power.

Oats, rolled

Cohen and Mendel, J. Biol. Chem. 35, 426, 1918.

Exclusive diet of oats produces rapid development of scurvy.

Germinated

Cohen and Mendel, J. Biol. Chem. 35, 425, 1918.

Exclusive diet maintained guinea pig without development of scurvy.

Furst, 1. c.

Sprouted oats valuable as antiscorbutic

Peas, germinated

Chick, Hume, and Skelton, Lane. 1919, ii, 774.

5 g. per day minimum dose affording protection.

Pulses (lentils, peas, and beans)

Comrie, Edin. Med. J. 207, 1930. Fiinrt, Z. Hyg. Infekt. 72, 121, 1912.

More

Lack t acquire it after

Germinated

Chick and Rhodes, J. Roy. Army Med. Corps, 38, 131, 1917.

Valual

Chick and Delf, Bioch. J. 13, 199, 1919.

beans or potatoes. Antiscorbutic ( to 6 fold on germinating 48 hours.

Seeds, dry

Davie, priv. com. 1920.

Ration y, com, oata, and guinea pigs about good condition reproduction was not successful.

Wheat embryo

Hess, Am. J. Dis. Child. 13, 98, 1917.

Antiscorbutic value very doubtful.

TUBERS AND ROOTS

SUBSTANCE

REFERENCE

REMARKS

Beet root

Chick and Rhodes, Lane. 1918, ii, 774.

Rather poor in C.

Juice

Chick, Hume, and Skelton, lb. 1919, ii, 774.

30 c. c. per day gives slight, but not complete protection.

Carrot juice

Holrt and Frolich, Z. Hyg. 72, 1, 1911.

Chick and Rhodes, 1. c

antiscorbutic power to 2.5 c.c.

Chick, Hume, and Skelton.

30 c. c. minimum dose giving protection.

Alc. ext

Zilva, Bioch. J. 11, 494, 1920.

Antiscorbutic present.

Onion, raw

Muneon, Theory and Practice of Mil. Hyg. N. Y. 1901.

Especially valuable prophylactic against scurvy.

Boiled

Davie, priv. com. 1930.

20 g. per day failed to protect, although one guinea pig was successfully reared to the age of 130 days with onion as sole source of C.

Potato, raw

Muneon, 1. c.

last scurvy.

Givens and McClugage, J. Biol. Chem. 43, 491, 1920.

pigs on soy bean diet for at least 6 times as long as soy bean alone.

Besssonoff, C. r. 173, 92,1931.

Equal to cabbage or dandelion. (If potatoes are crushed action is much inferior).

Juice

Funk, J. Biol. Chem. 36, 409, 1916.

Besssonoff, 1. c.

than in equivalent (residue contains prac-

Cooked 1/2 hour in salt water

Hoist and Frftlich, Z. Hyg. 72, 1. 1913.

> protection.

Cooked

Hess and Fiah, Am. J. Dis. Child. 8, 386. 1914.

for children.

Steamed

Chick and Rhodes, Lane. 1918, ii, 774.

30 g. per day effective antiscorbutic.

Cooked 1/2 hour at 100o

Chick, Hume, and Skelton, Lane. 1919, ii, 774.

30 g. per day minimum dose affording protection.

Boiled

Davie, priv. com. 1920.

8 g. per day gives sufficient C for successful growth, but not more than 20 g. required for satisfactory but not complete

Givens and MeClugage, 1. c.

Cooking for 15 minutes at 100o does not appreciably reduce antiscorbutic power, cooking for an hour does.

Dried (commercial)

Hoist and Frolich, Z. Hyg. 72, 1, 1012.

No protection.

Dried at 37o

No protection.

Dried at 30o in vac.

No protection.

Dried at 65 to 70o and cooked

Givens and Cohen, J. Biol. Chem. 36, 127, 1918.

Equivalent of 5 g. raw per day gave no protection.

Givens and McClugage, I. c.

with temperature and duration 60o being apparently optimum dried at this temperature gives

Radish, pickled

Koga, Bul. Naval Med. Ass. Tokyo, 1920. p. 2.

Turnip, swede

Chick and Rhodes, Lane. 1918, ii, 774.

2.5 c. c. of expressed juice per day sufficient to protect guinea pigs against scurvy.

Chick, Hume and Skelton, lb. 1919, ii, 774.

Dehydrated vegetables

Hoist and Frolich, Z. Hyg. 72, 1, 1912: 75, 334, 1913.

Little or no antiscorbutic present.

Chick and Hume, Tr. Soc. Trap. Med. Hyg. 10, 141, 1917.

All dried foodstuffs tiding desiccated vegetables, more or in antiscorbutic

Hen and linger, J. Biol. Chem. 36, 479, 1918.

Little or no antiscorbutic power.

FRUITS

Apple, dried '

Davis, priv. com. 1930.

Affords some protection.

Banana

Suguira and Benedict, J. Biol. Chem. 30, 171, 1918.

Scurvy developed in some eases in rata fed exclusively on banana.

Lewie, lb. 40, 91, 1919.

25 g. per day added to diet of rolled oats protects against scurvy, smaller amounts insufficient.

Grape juice

Chick and Rhodes, Lane. 1918, ii, 774.

About one-tenti as efficient as orange juice.

. Dried

Givens and Macy, J. Biol. Chem. 46, xi, 1931.

C absent.

Grapefruit juice, dried

Givens and Macy, J. Biol. Chem. 40, xi, 1921.

Significant amount of C present.

Lemon juice, fresh

Chick, Hume, and Skelton, Lane. 1919, ii, 222.

1.5 c. c. per day minimum dose firing protection.

Dried

Givens and Macy, 1. c

Significant amount of C present.

Dried in vac

Bassett-Bmith, Lane. 1920, i, 1102.

Satisfactory prophylactic and cure for earlier stages of disease.

FRUITS (Coninued)

Substance

REFERENCE

REMARKS

Freed from citric add

Harden and Zilva, Bioch. J. 12, 270, 1918.

Powerful antiscorbutic

Harden Zilva, and Still, Lane. 1919, i, 17.

Lime juice, fresh preserved

Chick, Hume And Skelton, 1. c.

affording protection.

Funk, J. Biol. Chem. 26, 415, 1910.

Willcox, Lane. 1919, ii, 979.

J and salicylic acid d none at alt.

Orange juice

Chick and Rhodes, Lane. 1918, ii, 774.

little if any better than swede juice.

Coben and Mendel, J. Biol. Chem. 34, 425, 1918.

5 c. c. per day gives complete protection.

Hess, Proc. Soc. Exp. Biol. Med. Mar 15th, 1918.

Intravenous injection effective cure for scurvy.

Dried

Givens and MoClugage, Am. J. Die. Child. 18, 30, 1919.

Useful antiscorbutic.

Givena and Macy, J. Biol. Chem. 46, xi, 1921.

Retains antiscorbutic potency two years after dehydration.

McClendon, Bowers, and Sedgwick, lb. 46, ix, 1921.

Equivalent of 125 c c. fresh juice gave complete protection to guinea pigs.

Orange peel

Hess, Am. J. Die. Child. 12, 152, 1915.

Antiscorbutic present

Hess and Unger, J. Biol. Chem. 35, 479, 1918.

Marked antiscorbutic power.

Plums, pickled

Koga, Bui. Naval Med. Ass. Tokyo, 1920, p. 2.

No antiscorbutic power.

Prunes

Hess and Unger, 1. c.

Raspberry juice, dried

Givens and Macy, 1. c.

Tomato

Munson, Theory and Practice of Mil. Hyg. N. Y. 1901.

scurvy.

Hess and Unger, Proc. Soc. Exp. Biol. Med. 1ft, 1. 1918.

Good antiscorbutic, raw or canned.

Hess, N. Y. State J. Med. 20, 209; J. Am.

Med. Ass. 75, 568, 1920.

Most serviceable antiscorbutic for infants. Should be fed at the rate of about 30 g. (1 os.) per day.

Givens and McClugage, J. Biol. Chem. 37, 253, 1919.

10 g. per day efficient either as preventive or cure for guinea pigs on soy bean diet.

Dried

Givens and McClugage, J. Biol. Chem. 37, 253, 1919.

Retain significant amount of potency, whether dried at high temperature (55 to 60o C) or low temperatures (35 to 40° C).

Canned

Chick and Rhodes, quoted by Barnes and Hume, Bioch. J. 13,337,1910.

Confirm results of Hess and linger as to antiscorbutic value of canned tomatoes.

Tropical Fruits

"Amnhier " (mango preparation)

Chick, Hume, and Skelton, Lane 1919, ii, 323.

Slight protection but not complete.

"Anola" (dried fruit of Phyl-lanthuc embliea)

J. Calcutta Med. Phyi. 800.

Has antiscorbutic value.

Cecum

and Skelton, 1. c.

Slight protection in some cases but not complete.

Mango, dried

Charles Algman Bound. Com. Rep. 1884.

Has antiscorbutic value.

Tamarind

Chick, Hume, and Skaltonn, 1. c.

3 to 5 g. per day retarded but did not prevent onset of scurvy.

Willcox, Lanc. 1919, ii, 979.

Some value as antiscorbutic.

Miscellaneous

Bear

Smith, Lanc. 1917, ii, 813.

antiscorbutic kilned malt

Dyke, Lanc. 1918, ii, 513.

antiscorbutic.

Cider, commercial pasteurised

Davis, priv. com. 1920.

Honey

Faber, J. Biol. Chem. 43, 113, 1920.

Hawk, Smith and Bergeim, Am. J. Physiol. 56, 339, 1931.

No protection afforded to guinea pigs.

Lactose

Cohen and Mendel, lb. 36,426, 1918.

No demonstrable antiscorbutic.

Hart, Steenbock, and Smith, lb. 38, 306, 1919.

No demonstrable antiscorbutic.

Lactose and other carbohy-drates

Harden and Zilva, Bioch. J. 12, 370, 1918,

No demonstrable antiscorbutic.

Halt soup

Gentenberger, Am. J. Die. Child. 21, 315, 1921.

May possess barley is of proper age or possesses an unusuall

Yeast

Hen, Am. J. Dis. Child. 13, 98, 1917.

No antiscorbutic value.

Cohen and Mendel, J. Biol. Chem. 35, 432, 1918.

No antiscorbutic value demonstrable.