Alkali therapy has, of course, also been tried in coma itself. In this condition it is necessary to work quickly, and for this reason Naunyn has advised administering alkalies intravenously 35 to 40 grm. of carbonate of soda (not bicarbonate) are dissolved in a litre of water. With care the whole litre can be injected at once. If necessary the infusion is to be repeated. It is dangerous to inject such strong solutions of soda subcutaneously, for gan grene almost invariably results. Infusion into the blood stream, however, is remarkably well borne. We have repeatedly seen patients who were unconscious regain consciousness while the infusion was being performed. After the infusion of alkalies, the internal administration by mouth is the most valuable means at our disposal, and it is often possible to administer from 80 to 120 grm. of carbonate of soda a day. According to the reports published by Naunyn and by A. Magnus-Levy and observations by von Noorden it is occasionally possible to overcome coma in this way and to restore the patient to a fairly comfortable condition. Unfortunately, such cases are the exception, and as a rule the favorable results, if they are obtained at all, are in the majority of cases transitory and of very short duration. Within a few hours or half a day fate usually claims its victim.