This crasis has the greatest resemblance with the exanthematous, and the disease assimilates so closely in its manifestations during life to typhus [intestinal typhus], as only to be distinguishable from the latter by the absence of abdominal symptoms, the more marked phenomena pointing to exudation in the membranes of the brain and upon the linings of its ventricles.

The product of this crasis is a tubercle presenting many peculiarities. It is a scattered corpuscle, mostly smaller than a millet-grain, and no bigger than a poppy-seed, or even a pin's point. It is now of glassy transparency, vesicle-like; now grayish, semi-opaque, soft, gluey; - then, again, verging upon whitish, or yellowish-white, and opaque. "With it there always exudes a grayish, more or less albumen-sated, semi-gelatinous serosity, infiltrating - drenching - the involved textures. The deposition of these products always affects an organ in wide extension.

Generally speaking, indeed, several organs are implicated at once, more especially the lungs, the cerebral pia mater, the spleen, the liver, and the serous membranes. The tubercle is always deposited in great numbers, and is equably disseminated throughout an organ, as the examination of an involved lung or spleen shows at a glance.

The tubercle is sometimes primitive, but more commonly successive to a pre-existent fibrin-tuberculosis. Looking at the physical properties of this tubercle, apart from any chemical analysis, and connecting it with the crasis of which it is the product, we are constrained to set it down as an albuminous formation.

With reference to the crasis itself, which, as we have said, is marked by a hypinosis closely resembling the exanthematous, it may be asked [and the question is replete with interest]: is acute tuberculosis primitive, or is it but a consecutive state of defibrination of the blood, brought about through the antecedent out-throwing of a large proportion of fibrin, in the shape of tubercle?

Or is it one of the so common tuberculoses connected with hydrocephalic effusion of the internal membranes of the brain, that is, consecutive hypinosis, determined by disease of the brain?

Seeing that acute tuberculosis occurs under conditions which preclude either of the contingencies here referred to, not a doubt can remain as to its protopathic character.

A further question is: how, in this hypinotic crasis, is the tubercle brought about?

[For a reply to this question the reader is, to avoid entire repetition, referred to the section on "Albuminous Tubercle," in the present volume, p. 246].

Acute tuberculosis probably always proves fatal.

Occasionally, owing to very extensive deposition, the crasis approximates to hydraemia. It does not pass into putrid decomposition, nor is it converted into pyaemia. On the other hand, acute softening of the stomach is a frequent follower in its train.

The corpses present, generally speaking, the same phenomena as in typhus; namely, pale skin, extensive, deep-colored patches of lividity, tense, dark-colored muscles, hypostatic hyperremise. The parenchymata, especially those which have been the seat of tubercle-deposition, are tur-gescent, and drenched with sero-albuminous fluid.